“One of the theories about Botox treating depression is that it doesn’t make you smile, but it stops you from frowning. Fake it until you make it! Some of the patients in our studies didn’t like the way they looked with Botox, but were likely to see their depression get better…It’s very exciting to have another possible tool, but I don’t think it’ll replace antidepressants. I think it means we need to start thinking outside the box.”